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The 50th ISCEV2012 Symposium will be held at the Colegio Oficial de Médicos de Valencia (Av. Plata, 20, 46013. Valencia) and the ISCEV Course at the Fundación Oftalmológica del Mediterráneo FOM (Bifurcación Pío Baroja – General Avilés, 46015 Valencia), an international research and clinical centre ideally located in Valencia city, both with excellent links into the city centre by metro and bus. The International Society for Clinical Electrophysiology of Vision, is a community of practice regrouping basic and clinical scientists, clinicians, as well as students coming from a wide variety of backgrounds including ophthalmology, optometry, medical physics, neuropsychology, psychology and biology. Some objectives of the society are: 1) To promote and extend the knowledge of clinical electrophysiology of vision. 2) To promote co-operation and communication among workers in the field of clinical and basic electrophysiology of vision. 3) To establish and continually revise norms for instrumentation, recording procedure and measurement in clinical electrophysiology of vision. These objectives are promoted through ongoing activities including publication of the scholarly Journal Document Ophthalmologica, web-based communications and support for regional and international meetings. The ISCEV annual symposium, the most important focus of the ISCEV calendar, rotates among three broad geographic regions: Europe and Africa, the Americas and Asia following invitation of individual members or local groups. There are close to 500 members from 45 countries who are bound together by a common interest in the human visual system in health and disease.